166 The Gut-Skin axis in common skin disorders

The gut counts trillions of microorganisms, while the skin is covered with billions microbes, mostly bacteria, but also fungal, archaeal, and viral species that inhabit its appendages. microbiome a key regulator for immune system aims to maintain homeostasis by communicating tissues organs in bidirectional manner. A barrier disruption combination an imbalance and/ or correlated altered response, which promotes development several diseases including psoriasis, dandruff seborrheic dermatitis, atopic rosacea, acne vulgaris, even cancer. These disorders quite often co-occur comorbidities, example 30% psoriasis patients suffer from Inflammatory Bowel Disease, rosacea have higher risk develop Small Intestinal Bacterial Overgrowth. We study facial scalp disorders. described underlying mechanisms nine common pathologies current body evidence dysbiosis, dietary links, their interplay conditions. Targeting via gut-skin axis may offer new therapeutic strategies health disease.